First of all, thanks for discussing this everyone, it’s really great to interact with such an engaged community.
The reason I looked into using FHS on MacOS is because I have failed at getting some derivations to build on MacOS – deriviations that work fine on NixOS and Linux. See here for example. Motivated by this post and by the way I use Julia-lang under NixOS (as an FHS env) I thought, as a stop-gap measure, I would try ceding package/env management back to the R-lang environment management tool renv by using an FHS env.
I am definitely keen to hear thoughts, suggestions, opinions regarding this … situation.