You can get rid of most fluff with something like this:
{
imports = [
<nixpkgs/nixos/modules/profiles/headless.nix>
<nixpkgs/nixos/modules/profiles/minimal.nix>
];
# only add strictly necessary modules
boot.initrd.includeDefaultModules = false;
boot.initrd.kernelModules = [ "ext4" ... ];
disabledModules =
[ <nixpkgs/nixos/modules/profiles/all-hardware.nix>
<nixpkgs/nixos/modules/profiles/base.nix>
];
# disable useless software
environment.defaultPackages = [];
xdg.icons.enable = false;
xdg.mime.enable = false;
xdg.sounds.enable = false;
}