@wirew0rm, got it working, it seems to require a special version of mono supplied by PS 
PR here: picoscope: init at 6.14.44-4r5870 by expipiplus1 路 Pull Request #122160 路 NixOS/nixpkgs 路 GitHub
This version of mono has heaps of references to /opt and whatnot in its config files, so I opted for a FHS wrapper.
I鈥檝e tested this on my 2006B MSO and basic functionality at least seems to work. The font scaling is a bit whack though, but that鈥檚 a common complaint on the PS forums dating back years, so I don鈥檛 think it鈥檚 an artifact of this packaging.
