Set NixOS program module options on a per-user basis?

Without resorting to home-manager, is it possible to set NixOS program module options on a per-user basis? For example, I would like to have the equivalent of programs.lesspipe.enable = true for my primary user but programs.lesspipe.enable = false for root.

(I’m avoiding home-manager because of the complexity overhead and because some essential patches for my system build didn’t make the cut for 25.05.)