Hi there, some news on that, someone answer on DrDuh yubikey issue (Questions about gpg smard card functionalities and yubikey configured with agent forwarding · Issue #212 · drduh/YubiKey-Guide · GitHub) that everything was possible (really ?). I doubt about the “challenge/response”, but i will try …
Actually the bug on pinentry is a problem to investigate more this, but nothing new on this point :
https://github.com/NixOS/nixpkgs/issues/97861