The best way in my opinion is to revise that list and trim it down to the inputs you actually need…
Other than that, what is the perceived problem with them? My biggest flake (system and home configuration) currently has 13 distinct inputs, and I have no problems managing those.
Where “managing” means, just leave them sit at the bottom of my flake.nix and never touch them again after they have been added, unless I know that I do not need them anymore…
The major workload will be dealt with by nix flake update, which again happens on CI…