Sound only works while pavucontrol is open

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I hate to be that guy, but I just recommend switching to Pipewire with Pulseaudio emulation. In my experience this fixes pretty much all problems that people have with sound.

Quoting from Headphone volume resets itself to 100% - #2 by hmenke

{
  hardware.pulseaudio.enable = false;
  security.rtkit.enable = true;
  services.pipewire = {
    enable = true;
    alsa.enable = true;
    alsa.support32Bit = true;
    pulse.enable = true;
  };
}

I do not recommend using the Jack emulation ( services.pipewire.jack.enable = true ) at this point because it uses LD_LIBRARY_PATH which breaks some applications (Evolution, epiphany: Webkitgtk bubblewrapper crashes when LD_LIBRARY path points into /run/current-system/** (the case on a pipewire system with jack emulation) · Issue #110468 · NixOS/nixpkgs · GitHub).

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