Using poetry2nix for local development

I’m wondering whether there are python developers that are using poetry2nix as their main way to handle dependencies instead of using a virtualenv(+poetry) when developing their project.

I’m working in a project where poetry2nix doesn’t work out of the box due to an incompatiblity, but I’m considering fixing the issues to make use of Nix caching, which I guess could help with some of the natively build dependencies.

What are your experiences?