What are the closest alternatives to qubes in Qubes OS?

I know of appvm but it’s abandoned and didn’t work on my machine. There’s also Spectrum OS but unfortunately it’s not usable yet.

Basically, what I’d like to do is run certain apps in a vm and integrate them into the host’s desktop environment. Like nixos containers but with a virtual machine.

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That would be Kata containers but sadly these are not supported in Nix, Package Request: Kata Containers · Issue #138595 · NixOS/nixpkgs · GitHub
Mentioned in that request you see the MicroVM’s from Astro, GitHub - astro/microvm.nix: NixOS MicroVMs
That could be the way for you

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