I am on unstable (wayland) and after a recent update my google-chrome started to load pages especially slow, there is no issue in firefox.
I tried to clean GPUCache with
I guess you might do that like on any other Linux machine. It depends what your DNS resolver is. In my case that is dnsmasq. But for some people it might also be systemd-resolved. In case of dnsmasq you might just kill the process, I hope that would do it. For systemd-resolved there is an option to flush the cache.
I suspect something is wrong with DNS lookup or so, not sure.